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KMID : 0892920130220010031
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Experimental Neurobiology
2013 Volume.22 No. 1 p.31 ~ p.37
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AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease
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Baek In-Sun
Kim Tae-Kyung
Seo Ji-Seon
Lee Kang-Woo
Lee Young-Ae
Cho Jae-Young
Gwag Byoung-Joo
Han Pyung-Lim
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Abstract
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Alzheimer's disease (AD) is a neurodegenerative disease that proceeds with the age-dependent neuronal loss, an irreversible event which causes severe cognitive and psychiatric devastations. In the present study, we investigated whether the compound, AAD-2004 [2-hydroxy-5-[2-(4-trifluoromethylphenyl)-ethylaminobenzoic acid] which has anti-oxidant and anti-inflammatory properties, is beneficial for the brain of Tg-betaCTF99/B6 mice, a murine AD model that was recently developed to display age-dependent neuronal loss and neuritic atrophy in the brain. Administration of AAD-2004 in Tg-betaCTF99/B6 mice from 10 months to 18 months of age completely repressed the accumulation of lipid peroxidation in the brain. AAD-2004 markedly suppressed neuronal loss and neuritic atrophy, and partially reversed depleted expression of calbindin in the brain of Tg-beta-CTF99/B6. These results suggest that AAD-2004 affords neurodegeneration in the brain of AD mouse model.
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KEYWORD
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Alzheimer's disease, neuronal loss, neuritic atrophy, neuroprotection, small molecule
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